Prescription weight loss medication
Compounded Semaglutide
Semaglutide is a GLP-1 receptor agonist. Compounded semaglutide is a custom-prepared medication that an independent licensed provider may prescribe. It is not FDA-approved.
Not FDA-approved. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness, or quality. They are prepared by state-licensed pharmacies on a provider's prescription for an individual patient.
Formulation
Compounded semaglutide and compounded tirzepatide are offered as injectable medication prepared by VialsRx, a licensed U.S. pharmacy. Which medication and formulation you receive is decided by your provider, and is subject to clinical eligibility and current availability.
Compounded Semaglutide vs. Compounded Tirzepatide
How it differs from tirzepatide
Semaglutide and tirzepatide are both compounded GLP-1 medications, but they aren't the same drug. Semaglutide acts on a single hormonal pathway, the GLP-1 receptor. Tirzepatide acts on two, the GLP-1 and GIP receptors. That mechanical difference is what separates the two medications, not a difference in how they're prescribed, dosed, or shipped through Mazrek.
Who typically considers semaglutide
Semaglutide is often the first GLP-1 medication a provider considers for someone starting treatment, since it has a longer track record as a single-pathway option. It's also a common choice for people who want to start with a more established mechanism, or whose provider prefers to titrate a single-pathway medication first before considering an alternative. Whether semaglutide, tirzepatide, or neither is right for you is a clinical decision your provider makes after reviewing your health history, not something you choose off a menu.
This page is not a substitute for medical advice, and it doesn't claim one medication works better than the other. Individual response varies, and only your provider can decide which medication, if any, fits your health history and goals. See Compounded Tirzepatide.
Pricing
Starting at $89/month on the 12-month plan. The price is the same at every dose, so there is no pricing by dose. See all GLP-1 pricing.
| Plan | Price per month | Billing frequency | Total charged at checkout |
|---|---|---|---|
| Monthly | $139/mo | Every month | $139 |
| 3 months | $109/mo | Every 3 months (quarterly) | $327 for 3 months |
| 6 months | $99/mo | One payment, up front | $594 for 6 months |
| 12 months | $89/mo | One payment, up front | $1,068 for 12 months |
What's included
- Review of your health intake by a licensed U.S. provider
- If prescribed, the medication, prepared by VialsRx, a licensed U.S. pharmacy
- Injection supplies
- Free shipping, typically 2 to 5 days
- Secure messaging with your care team and dose adjustments by your provider
- No membership fee
How eligibility and prescribing work
- You complete a short online health intake. A licensed U.S. provider reviews it. Not everyone is prescribed treatment.
- Mazrek is a technology platform. Prescribing decisions are made only by the independent licensed provider, never by Mazrek.
- Your provider decides whether treatment is appropriate, which medication, and your dose and titration schedule.
- You must be 18 or older.
- If you are not a candidate, no prescription is issued.
Safety information
Boxed warning: thyroid C-cell tumors
- In rodent studies, semaglutide caused thyroid C-cell tumors. It is not known whether it does in humans, including medullary thyroid carcinoma (MTC).
- Do not use if you or a family member has had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Tell your provider right away about a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath.
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Stomach pain
- Headache and fatigue
Serious risks to report immediately
- Pancreatitis (severe, persistent abdominal pain, with or without vomiting)
- Gallbladder problems, including gallstones
- Dehydration and kidney problems, usually after vomiting or diarrhea
- Serious allergic reactions (swelling of the face, lips or throat, trouble breathing)
- Low blood sugar, especially if you also take insulin or sulfonylureas
- Changes in vision, for people with diabetic retinopathy
Who should not use it
- People who are pregnant, planning pregnancy, or breastfeeding
- Anyone allergic to semaglutide or any ingredient in the preparation
- Anyone with a personal or family history of MTC or MEN 2
This is general information, not medical advice, and it is not a complete list of risks. Your provider will review risks with you before prescribing. In an emergency, call 911. You can report side effects to your care team at support@joinmazrek.com or to the FDA at www.fda.gov/medwatch. See also Safety & Legal.
Billing, shipping and renewal
- Dose-based pricing
- There is none. The price is the same at every dose. If your provider raises or lowers your dose, your price doesn't change.
- Membership fees
- No membership fee. The plan price covers your medication, provider care, and injection supplies.
- Shipping
- Shipping is included at no extra charge, typically 2 to 5 days, to all 50 states.
- Renewal
- Plans renew automatically at the end of each term at the rate shown for that term. You can cancel or pause through your patient portal, or by emailing support@joinmazrek.com, before your next billing date. Cancellation applies to future renewals only.
- Refunds
- Refund eligibility depends on how far your order has progressed. Once a prescription has been sent to the pharmacy, the order is final. Read the full refund policy in the Terms of Service.
- Insurance
- Mazrek is cash-pay and does not bill insurance.
Common questions
No. Compounded semaglutide is custom-prepared by a licensed pharmacy for an individual patient. The FDA does not review it for safety, effectiveness, or quality.
No. The plan price is the same at every dose.
The intake is only needed if you decide to start treatment.